Staff Profiles

Dr. Ezra Kombo Osoro

osoroContact Details

Department of Medical Biochemistry,

School of Medicine,

P.O. Box 190 – 50100 Kakamega, Kenya

Office MED Block 3rd floor Room 3

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

ORCID: https://orcid.org/0000-0001-6565-5911.

ResearcherID: AAZ-3414-2021

Google Scholar:  oZuhUmUAAAAJ&hl=en

Dr. Ezra Kombo Osoro

Dr. Ezra Kombo Osoro is a Lecturer in the Department of Medical Biochemistry at the School of Medicine. He holds a doctorate and MSc. degree in Biochemistry and Molecular Biology. He also holds a MSc. Degree in Bioinformatics. His Bachelors degree is in Biochemistry and Molecular Biology.  He is an expert in medical biochemistry, and his research focuses on the investigation of molecular mechanisms of complex diseases including diabetes kidney disease, Non-alcoholic fatty liver disease and Rheumatoid arthritis with the hope of identifying molecular therapeutic targets..

Some of his major Publications:

  1. Nyabera Nicholas Mogoi, Anthony Wawire Sifuna, Patrick Kirsteen Okoth, Oleg Reva, Rose Malaba, Ruth Negesa​, Kuloba Peter Nyongesa, Kombo Ezra Osoro and Martin Welch. Staphylococcus aureus associated with surgical site infections in Western Kenya reveals genomic hotspots for pathogen evolution. Published on 27 July 2024 in Microbiology Society. DOI:https://doi.org/10.1099/acmi.0.000734.v4
  2. Millicent Muthoni Muriuki, Peterson Mwangi, Ezra Kombo Osoro, Miriam Miima. Knowledge, Attitudes, and Practices among Healthcare Workers regarding Depression Care in Two Medium-Sized Hospitals in Kenya. published on 07 June 2024 in Wiley Depression and Anxiety. DOI: https://doi.org/10.1155/2024/4756962
  3. Erick Barasa,Briston Indieka,Nathan Shaviya,Ezra Osoro,Geofrey Maloba,Denis Mukhongo,Valentine Budambula,and Tom Were Assemblages and Subassemblages of Giardia duodenalis in Rural Western, Kenya: Association with Sources, Signs, and Symptoms. Published on 5th February 2024 in Journal of Parasitology Research. DOI: https://doi.org/10.1155/2024/1180217
  4. Ezra Kombo Osoro, Shemin Lu. Recent Advances of Autophagy in Diabetic Kidney disease. Renal Failure. 2022 (Under Review) (SCI, Impact factor: 2.46).
  5. Huang Huang, Jidong Yan, Xi Lan, Yuanxu Guo, Ezra Kombo Osoro, Weikun Hou, Lisong Heng, Mengyao Sun, Yitong Zhao, Fujun Zhang, Peng Xu, Jian Sun and Shemin Lu. Binding of PABPC1 to LncRNA WDR11-AS1 accelerates cartilage degradation in osteoarthritis by regulating SOX9 mRNA decay Arthritis Research & Therapy 2022 (SCI, Impact factor: 4.02) (UNDER REVIEW)
  6. Xiaojuan Du; Ezra Kombo Osoro; Qian Chen; Xiaofei Yan; Dan Gao; Litao Wu; Bo Zhong; Lina Feng; Nan Wu; Xudong Yang; Yan Han; Fujun Zhang; Dongmin Li; Xi Lan. Pdcd4   promotes lipid deposition by attenuating PPARα mediated fatty acid oxidation in hepatocytes. Molecular and Cellular Endocrinology. 2022 Jan 23. Doi: DOI: https://doi.org/10.1016/j.mce.2022.111562.
  7. Ezra Kombo Osoro, Xiaojuan Du, Dong Liang, Xi Lan, Riaz Farooq, Fumeng Huang Wenhua Zhu, Jiajun Ren, Muhammad Sadiq, Lifang Tian, Xudong Yang, Dongmin Li, and Shemin Lu 2021 Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5. Biochemistry and cell biology. 2021 Oct;99(5):617-628.Epub 2021 Apr 8. PMID: 33831322. DOI: https://doi.org/10.1139/bcb-2021-0028
  8. Dong Liang*, Ezra Kombo Osoro*, Shuai Tan, Xi Lan, Wenhua Zhu, Litao Wu, Xiaojuan Du, Dongmin Li, and Shemin Lu. 2020. “Effects and Mechanisms of Autophagy Induced by Solubilized-Cholesterol in Hepatocytes : A Comparative Study Among Solvents.” Cell Biochemistry and Biophysics. DOI: https://doi.org/10.1007/s12013-020-00917-2
  9. Riaz, Farooq, Qian Chen, Kaikai Lu, Ezra Kombo Osoro, Litao Wu, Lina Feng, Rong Zhao, Luyun Yang, Yimeng Zhou, Yingli He, Li Zhu, Xiaojuan Du, Muhammad Sadiq, Xudong Yang, and Dongmin Li. 2021. “Inhibition of MiR‐188‐5p Alleviates Hepatic Fibrosis by Significantly Reducing the Activation and Proliferation of HSCs through PTEN/PI3K/AKT Pathway.” Journal of Cellular and Molecular Medicine 00: jcmm.16376. DOI: https://doi.org/10.1111/jcmm.16376.
  10. Wu, Litao, Juan Sun, Li Liu, Xiaojuan Du, Yan Liu, Xiaofei Yan, Ezra Kombo Osoro, Fujun Zhang, Lina Feng, Dong Liang, Yazhao Li, Qian Chen, Sha Sun, Lei Zhang, Xi Lan, Dongmin Li, and Shemin Lu. 2020. “Anti-Toll-like Receptor 2 Antibody Ameliorates Hepatic Injury, Inflammation, Fibrosis and Steatosis in Obesity-Related Metabolic Disorder Rats via Regulating MAPK and NF-ΚB Pathways.” International Immunopharmacology 82(February):106368. DOI: https://doi.org/10.1016/j.intimp.2020.106368
  11. Lan, Xi, Nan Wu, Litao Wu, Kai Qu, Ezra Kombo Osoro, Dongxian Guan, Xiaojuan Du, Bo Wang, Sifan Chen, Ji Miao, Juan Ren, Li Liu, Haiyun Li, Qilan Ning, Dongmin Li, and Shemin Lu. 2020. The Human Novel Gene LNC-HC Inhibits Hepatocellular Carcinoma Cell Proliferation by Sequestering Hsa-MiR-183-5p. Molecular Therapy - Nucleic Acids 20: 468-479. DOI: https://doi.org/10.1016/j.omtn.2020.03.008
  12. Lan, Xi, Litao Wu, Nan Wu, Qian Chen, Yue Li, Xiaojuan Du, Chenxi Wei, Lina Feng, Yazhao Li, Ezra Kombo Osoro, Mengyao Sun, Qilan Ning, Xiaofei Yan, Xudong Yang, Dongmin Li, and Shemin Lu. 2019. “Long Noncoding RNA Lnc-HC Regulates PPARγ-Mediated Hepatic Lipid Metabolism through MiR-130b-3p.” Molecular Therapy - Nucleic Acids 18(December):954–65. DOI: https://doi.org/10.1016/j.omtn.2019.10.018
  13. Zhang, Lin, Zhi Yuan Shen, Ke Wang, Wei Li, Jing Ming Shi, Ezra Kombo Osoro, Naeem Ullah, Yan Zhou, and Shang Rong Ji. 2019. “C-Reactive Protein Exacerbates Epithelial-Mesenchymal Transition through Wnt/β-Catenin and ERK Signaling in Streptozocin-Induced Diabetic Nephropathy.” FASEB Journal 33(5):6551–63. DOI: https://doi.org/10.1096/fj.201801865RR
  14. Hussain, S., M. Sun, Y. Guo, N. Mushtaq, Y. Zhao, Y. Yuan, N. Hussain, Ezra kombo Osoro, A. Suleiman, M. Sadiq, F. Zhang, Y. Han, J. Sun, and S. Lu. 2018. “SFMBT2 Positively Regulates SOX9 and Chondrocyte Proliferation.” International Journal of Molecular Medicine 42(6).  DOI: https://doi.org/10.3892/ijmm.2018.3894.
  15. LI Yue, LAN X, WU Litao, DU Xiaojuan, Ezra Kombo Osoro, LI Dongmin, LU Shemin.’Bidirectional regulation of Pam3CSK4-induced inflammatory response by ATP-bindingcassette transporter A1 knockdown in mouse mononuclear macrophagesin in vitro ‘J South Med Univ, 37(12): 1563-1569. DOI: https://doi.org10.3969/j.issn.1673-4254.2017.12.01.

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